Essential role for caspase-8 in toll-like receptors and nfκb signaling*

HIGHLIGHTS

• who: Bénédicte Lemmers from the (UNIVERSITY) have published the research work: Essential Role for Caspase-8 in Toll-like Receptors and NFκB Signaling*, in the Journal: (JOURNAL) of July/14,/2006
• what: To investigate the mechanisms leading to the defective NF␬B-mediated responses of TLR4-stimulated casp8⫺/⫺ B cells, the authors focused on known signaling events downstream of LPS/TLR4 activation, including Akt, MAPK-p38, and IkB␣ phosphorylation. The authors report important roles for caspase-8 in the regulation of NF␬B function in response to TLR4 stimulation.

SUMMARY . . .

 

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