HIGHLIGHTS
- who: System Administrator from the University of have published the research: Depolarization and CaM Kinase IV Modulate NMDA Receptor Splicing through Two Essential RNA Elements, in the Journal: (JOURNAL)
- what: The authors characterize the response of NMDAR1 E21 to depolarization and activated CaMK IV. The authors show that the splicing of an important exon (E21) in the NMDA receptor subunit NR1 mRNA is repressed by cell depolarization and activation of the intracellular signaling molecule, CaMK IV. The authors show that membrane depolarization in P19 cells represses the splicing of the NR1 E21, whereas the ratio . . .
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