HIGHLIGHTS
- who: Azad Farzadfard from the (UNIVERSITY) have published the research work: Glycation modulates alpha-synuclein fibrillization kinetics: A sweet spot for inhibition, in the Journal: (JOURNAL)
- what: The authors show glycation primarily inhibits elongation rather than nucleation of u03b1SN and has only a modest effect on the level of oligomerization. The authors propose that this optimal level balances the affinity for the growing ends of the fibril (which decreases with the extent of modification) with the ability to block incorporation of subsequent u03b1SN subunits (which increases with modification). As shown in Figure 4, A and . . .
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