Hepatic insulin receptor deficiency impairs the srebp-2 response to feeding and statins[s]

HIGHLIGHTS

• who: Ji Miao from the DivisionUniversity of have published the research work: Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins[S], in the Journal: (JOURNAL) of February/10,/2014
• what: The authors show that LIRKO mice manifest decreased nuclear SREBP-2 protein, decreased cholesterologenic gene_expression, and decreased cholesterol synthesis.

SUMMARY

The authors show that LIRKO mice manifest decreased nuclear SREBP-2 protein, decreased cholesterologenic gene_expression, and decreased cholesterol synthesis. The authors used oligonucleotide microarrays to query, in a nonbiased manner, the effects of hepatic insulin signaling . . .

 



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