Anti-cd154 mab and rapamycin induce t regulatory cell mediated tolerance in rat-to-mouse islet transplantation

HIGHLIGHTS

• who: Anti-CD and colleagues from the Surgical Research Unit, Department of Surgery, University Hospital Geneva, Geneva, Switzerland, Service of Clinical Immunology and Allergology, Department of have published the research work: Anti-CD154 mAb and Rapamycin Induce T Regulatory Cell Mediated Tolerance in Rat-to-Mouse Islet Transplantation, in the Journal: (JOURNAL) of April/26,/2010
• what: This study investigated the effect of combined RAPA/MR1 treatment on rat-to-mouse islet xenograft survival and analyzed the role of CD4+CD25+Foxp3+ cells (Treg) in the induction and maintenance of the ensuing tolerance.
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