HIGHLIGHTS
- who: Belu00e9n Borrego from the (CSIC), Spain have published the article: Identification of Single Amino Acid Changes in the Rift Valley Fever Virus Polymerase Core Domain Contributing to Virus Attenuation In Vivo, in the Journal: (JOURNAL)
- what: The authors focused on those in residues 924, 1050 and 1303 because of their location in the catalytic core of the RNA-dependent RNA_polymerase (RdRp). The authors show that the substitution of only two amino_acids, G924S and A1303T, in the polymerase of a virulent RVFV (rZH548) is enough to strongly attenuate the virus without loss of protective immunogenicity . . .
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