Phosphorylation of histone h3 by protein kinase c signaling plays a critical role in the regulation of the developmentally important tbx2 gene*

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• who: Huajian Teng from the Huajian Teng, Reyna Deeya Ballim, Shaheen Mowla, and Sharon Prince, From the Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa The mechanism(s) regulating the expression of the , gene, a key regulator of development, is poorly understood and thus limits an understanding of its function(s)Here we demonstrate that, tetradecanoylphorbol-13-acetate (TPA) induces , expression in normal human fibroblasts in a protein kinase C (PKC)-dependent and MAPK-independent manner. Our data further reveal that TPA activates transcription of , through activating MSK1 . . .
  

   

  

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