Mutations targeting intermodular interfaces or calcium binding destabilize the thrombospondin-2 signature domain*

HIGHLIGHTS

• who: C. Britt Carlson from the CBritt Carlson1, Kristin A. Gunderson, and Deane F. Mosher, From the Departments of Medicine and Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin , Thrombospondins (THBSs) are a family of secreted calciumbinding glycoproteins with roles in angiogenesis, cell motility, apoptosis, cytoskeletal organization, and extracellular matrix organization. The , signature domain (three epidermal growth factor (EGF)-like modules, a wire module with , calcium-binding repeats, and a lectin-like module) binds , calcium ions and forms extensive interactions among its parts. We explored the significance of these structural elements by examining the impact of , different . . .
  

   

  

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