Accumulation of free adp-ribose from mitochondria mediates oxidative stress-induced gating of trpm2 cation channels*

HIGHLIGHTS

• who: Anne-Laure Perraud from the (UNIVERSITY) have published the paper: Accumulation of Free ADP-ribose from Mitochondria Mediates Oxidative Stress-induced Gating of TRPM2 Cation Channels*, in the Journal: (JOURNAL) of November/18,/2004
• what: The authors show through structure-guided mutagenesis that TRPM2 gating by ADP-ribose and both oxidative and nitrosative stresses requires an intact ADP-ribose binding cleft in the Cterminal nudix domain. As an initial step toward obtaining insight into potential alternative TRPM2 gating mechanisms, the authors focused on obtaining an improved understanding of NUDT9-H domain interactions with NAD . . .
  

   

  

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