HIGHLIGHTS
- who: Chiara Maniaci from the School University of have published the Article: Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: To provide proof-ofconcept for the approach, the authors designed, synthesized and tested homo-bivalent molecules aiming to target CRL2-VHL, the E3 ligase that targets for ubiquitination and degradation the hypoxia inducible factor alpha subunit (HIF-u03b1) under normoxic conditions49. The authors show the most active compound, CM11, made of two instances of a potent hydroxyproline (Hyp) containing . . .
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