Poly(adp-ribose) polymerase 1 (parp1) restrains myod-dependent gene expression during muscle differentiation

HIGHLIGHTS

• who: Francesca Matteini from the InstitutSapienza University have published the Article: Poly(ADP-ribose) Polymerase 1 (PARP1) restrains MyoD-dependent gene expression during muscle differentiation, in the Journal: Scientific Reports Scientific Reports
• what: The authors focused the attention on the p57 distal regulatory region KVDMR1 and on myogenin promoter, critical and well-characterized elements for the differentiation-dependent expression of the two genes. The authors provide evidence, for the first time, that PARP1 participates in the control of gene_expression during muscle differentiation and, in particular, the authors show that PARP1, independently of its enzymatic activity . . .
  

   

  

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