HIGHLIGHTS
- who: Rachel L. Edwards from the (UNIVERSITY) have published the research work: MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis, in the Journal: (JOURNAL) of 18/07/2016
- what: Taken together, the work demonstrates the antimalarial potential of RCB-185, and supports exploration of novel MEPicides as therapeutic agents. The authors report the discovery and characterization of RCB-185, a potent and specific MEPicide antimalarial that targets P. falciparum Dxr. Altogether, the studies demonstrate that these FSM-like compounds inhibit P. falciparum through direct Dxr inhibition, without substantial off-target effects, and that further investigation of . . .
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