Hiv-1 nef targets hdac6 to assure viral production and virus infection

HIGHLIGHTS

• who: Agustín Valenzuela-Fernández from the University of Toledo, United States have published the Article: HIV-1 Nef Targets HDAC6 to Assure Viral Production and Virus Infection, in the Journal: (JOURNAL)
• what: The authors propose a new function for Nef through targeting HDAC6, thereby neutralizing its antiviral functions. This fact may be indicative that this motif is involved in Nef-mediated HDAC6 processing, or that a conformational change in the mutated Nef protein abrogates the activity presented by other parts of the molecule, as observed with the full-length Nef .
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