Rex1 is the critical target of rnf12 in imprinted x chromosome inactivation in mice

HIGHLIGHTS

• who: Cristina Gontan from the Oncode Institute, Erasmus MC, , CA, Rotterdam, The Netherlands have published the research: REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show that REX1 is the prime target of RNF12 in ESCs. The authors propose a model where the Rnf12-Rex1 axis regulates initiation of iXCI and the maintenance of the Xi in the pre-implantation embryo (Fig 6). For the present study, the authors generated Rnf12CR-/CR- ESCs through complete removal of the open_reading_frame . . .
  

   

  

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