Immunopathogenic mechanisms of autoimmune hepatitis: how much do we know from animal models?

HIGHLIGHTS

  • who: Urs Christen and Edith Hintermann from the Goethe University Hospital, , have published the article: Immunopathogenic Mechanisms of Autoimmune Hepatitis: How Much Do We Know from Animal Models?, in the Journal: (JOURNAL)
  • what: The aim of the therapy is to induce AIH remission indicated by a normalization of the serum aminotransferase levels and a reduction of the hypergammaglobulinemia (see a more detailed review on the clinical treatment of AIH by Mann et_al ). This model demonstrated that infection with a liver-tropic pathogen (i.e., LCMV) as well as a the presence of liver autoantigen-specific . . .

     

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