Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule

HIGHLIGHTS

• who: from the (UNIVERSITY) have published the research work: Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule, in the Journal: (JOURNAL) of 25/07/2018
• what: As β-hydroxybutyrate is a central metabolic fuel, the authors focused the investigation on myotubes, as skeletal muscle is the quantitatively main tissue governing glucose disposal.
• how: Because of the chemical and functional similarity between the two molecules the authors compared here their impact on multiple cell types evaluating i) histone acetylation and hydroxybutyrylation levels by immunoblotting ii) transcriptional regulation . . .
  

   

  

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