3-deazaneplanocin a (dznep), an inhibitor of the histone methyltransferase ezh2, induces apoptosis and reduces cell migration in chondrosarcoma cells

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  • who: Histone Methyltransferase EZH and collaborators from the France, Department, University of Valencia, Valencia, Spain have published the article: 3-Deazaneplanocin A (DZNep), an Inhibitor of the Histone Methyltransferase EZH2, Induces Apoptosis and Reduces Cell Migration in Chondrosarcoma Cells, in the Journal: PLOS ONE | www.plosone.org of May/22,/2014
  • what: The aim of this study was to determine whether an epigenetic therapy targeting with DZNep may be also efficient to treat chondrosarcomas. The authors show that high grade chondrosarcomas express protein and that DZNep reduces its expression and subsequently H3K27me3. The authors show . . .

     

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