Both ubiquitin ligases fbxw8 and park2 are sequestrated into insolubility by atxn2 polyq expansions, but only fbxw8 expression is dysregulated

HIGHLIGHTS

• who: Melanie Vanessa Halbach and colleagues from the Deptof, Goethe University Medical School, Theodor Stern Kai, and Genetics Department, Boğaziçi University, Istanbul, Turkey have published the research: Both Ubiquitin Ligases FBXW8 and PARK2 Are Sequestrated into Insolubility by ATXN2 PolyQ Expansions, but Only FBXW8 Expression Is Dysregulated, in the Journal: PLOS ONE | DOI:10.1371/journal.pone [0121089]. March 19, 2015 of 24/Nov/1986
• what: The authors focused on in_vivo evidence from mouse brain and patient tissues, assessing whether (IV) FBXW8 also interacts with PARK2 in co-immunoprecipitation assays, (V) FBXW8 and . . .
  

   

  

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