Trehalose prevents aggregation of exosomes and cryodamage

HIGHLIGHTS

• who: Steffi Bosch from the Nantes University have published the research work: Trehalose prevents aggregation of exosomes and cryodamage, in the Journal: Scientific Reports Scientific Reports
• what: This study attempts to evaluate the potential benefits of 25 mM trehalose in PBS (TRE) to maintain dispersal, functionality and stability of beta-cell exosome-like vesicles (beta-ELV) during isolation and storage. The authors evaluate the aptitude of trehalose, a natural, non-toxic dispersion agent and cryoprotectant to preserve stability of ELV suspensions using protein, PSD, cryo-electron tomography, zeta potential, and cytokine secretion analyses.
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