HIGHLIGHTS
- who: Ulrich Koller from the University of Coimbra, Portugal Spain have published the article: COL17A1 editing via homology-directed repair in junctional epidermolysis bullosa, in the Journal: (JOURNAL)
- what: Interestingly, this experiment showed no clear advantage of_(low-level) HDR-mediated wild-type C17 restoration with respect to C17 function.
- future: Although the exact influence of indels generated at the targeting site on therapeutic outcomes needs to be thoroughly analyzed in future studies and may prove to be negligible for achieving skin integrity the restoration of fully functional wild-type protein is still . . .
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