Early enzyme replacement therapy prevents dental and craniofacial abnormalities in a mouse model of mucopolysaccharidosis type vi

HIGHLIGHTS

• who: MPS VI and collaborators from the University of Helsinki, Finland have published the Article: Early enzyme replacement therapy prevents dental and craniofacial abnormalities in a mouse model of mucopolysaccharidosis type VI, in the Journal: (JOURNAL)
• what: The authors examined skulls of 24-week-old Arsbm/m mice and control mice using contact radiography, microcomputed tomography (u03bcCT), and decalcified histology in comparison with craniofacial and dental findings from three MPS VI patients. The authors demonstrate that early administration of rhARSB replacement therapy can prevent the development of most craniofacial pathologies. The authors could show for . . .
  

   

  

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