Pharmacophore and molecular docking guided 3d-qsar study of bacterial enoyl-acp reductase (fabi) inhibitors

HIGHLIGHTS

• who: Xiaoyun Lu and collaborators from the Department of Medicinal Chemistry, China Pharmaceutical University, Tongjiaxiang, Nanjing have published the research work: Pharmacophore and Molecular Docking Guided 3D-QSAR Study of Bacterial Enoyl-ACP Reductase (FabI) Inhibitors, in the Journal: (JOURNAL)
• what: To speed up the analysis and reduce noise, a minimum filter value u03c3 of 2.00 kcal/mol was used.
• how: The results showed that the pharmacophore model is capable of reproducing the bioactive conformation from the Protein Data Bank and is reliable enough to retrieve compounds that fit all the features . . .
  

   

  

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