HIGHLIGHTS
- who: Marie Goulard from the INSERM, UMRS1131-Paris Diderot University, Saint Louis Hospital, Paris, France have published the Article: Role of the microenvironment in myeloid malignancies, in the Journal: (JOURNAL)
SUMMARY
Indeed, HSC fate has been proven to be highly specific, both in_vivo and in_vitro and defined by intrinsic epigenetic features. This function has been confirmed in an in_vivo model of CXCL12 silencing in the CAR cells. The MDS-MSCs enter senescence earlier than normal MSCs and display a senescent phenotype in_vitro. It has been demonstrated that MDS-MSCs have an impaired capacity . . .
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