Cocaine-mediated circadian reprogramming in the striatum through dopamine d2r and pparγ activation

HIGHLIGHTS

• who: Karen Brami-Cherrier from the University of, USA have published the paper: Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARu03b3 activation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: Using combined metabolomic and transcriptomic approaches, the authors show that D2R in iMSNs contributes to cocaine-induced activation of peroxisome protein activator receptor gamma (PPARu03b3), a nuclear receptor implicated in inflammatory responses30,31. Using PPARu03b3 nuclear-specific antibodies, the authors show that PPARu03b3 chromatin recruitment to Adora2a and Kcnd1 promoters was significantly reduced in iMSN-D2RKO animals as compared to WT . . .
  

   

  

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