Independent tubulin binding and polymerization by the proline-rich region of tau is regulated by tau`s n-terminal domain

HIGHLIGHTS

• who: Kristen M. McKibben from the (UNIVERSITY) have published the paper: Independent tubulin binding and polymerization by the proline-rich region of Tau is regulated by Tau`s N-terminal domain, in the Journal: (JOURNAL) of July/11,/2019
• what: The authors demonstrate that interactions between the PRR and MTBR are reduced by the NTD through a conserved conformational ensemble. On the basis of these results, the authors propose that Tau`s PRR can serve as a core tubulinbinding domain, whereas the MTBR enhances polymerization capacity by increasing the local tubulin concentration. The authors investigate . . .
  

   

  

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