Α-selenoconotoxins, a new class of potent α7 neuronal nicotinic receptor antagonists*

HIGHLIGHTS

• who: Christopher J. Armishaw from the (UNIVERSITY) have published the paper: u03b1-Selenoconotoxins, a New Class of Potent u03b17 Neuronal Nicotinic Receptor Antagonists*, in the Journal: (JOURNAL) of May/19,/2006
• what: The authors have investigated the impact of substituting disulfide bonds with diselenide bonds on the structure, activity, and conformational stability of a model cysteine-rich peptide in relevant biological reducing environments.

SUMMARY

Traditionally, cyclization is employed as a means of restricting a peptide to the bioactive conformation, which consequently increases receptor selectivity and in_vivo stability. Some biologically important peptides . . .

 



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