HIGHLIGHTS
- who: Dong Han et al. from the Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, China have published the research: MiR-124 and the Underlying Therapeutic Promise of Neurodegenerative Disorders, in the Journal: (JOURNAL)
SUMMARY
Ab activates the TNF-a-dependent intracellular signal_transduction pathway, leading to upregulation and activation of cyclooxygenase-2 (COX-2) expression, which ultimately leads to neuronal synaptic loss and cognitive decline (Tobinick, 2009; Medeiros et_al, 2010). Under the condition of AD pathology, dangerous-associated molecular patterns, amyloid-b peptide (Ab), neurotrophic plaques (NPs), Frontiers in Pharmacology | www . . .
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