Atypical α-conotoxin ltia from conus litteratus targets a novel microsite of the α3β2 nicotinic receptor*

HIGHLIGHTS

• who: Sulan Luo from the EXPERIMENTAL PROCEDURES Materials-Acetylcholine chloride, atropine, and bovine serum albumin were obtained from SigmaReversed-phase HPLC analytical Vydac , column (, u242em, ., u2afb , mm) and preparative , Vydac column (, u242em, u2afb , mm) were obtained from Shenyue (Shanghai City, China). Reagents for peptide synthesis were from Applied Biosystems (Guangzhou City, China). Acetonitrile was purchased from Fisher. Trifluoroacetic acid was from Tedia Co. (Fairfield, OH). All other chemicals used were of analytical grade. The sequence of u2423-conotoxin LtIA (GCCARAACAGIHQELC) was based on a cDNA clone (LeD P) from C. litteratus from Hainan, China (Table, ) (17). A . . .
  

   

  

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