Sfrp2 induces a mesenchymal subtype transition by suppression of sox2 in glioblastoma

HIGHLIGHTS

• who: Min Guo from the Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden have published the paper: SFRP2 induces a mesenchymal subtype transition by suppression of SOX2 in glioblastoma, in the Journal: (JOURNAL)
• how: SOX2-overexpression exhibits opposing effects on SFRP2 phenotypes To elucidate the connection between SFRP2 and SOX2 the authors conducted a set of experiments to see if SOX2overexpression mirrored SFRP2 phenotypes. To identify novel intermediate regulatory factors between SFRP2 and SOX2 the authors hypothesized that activity of such genes should increase or decrease upon SFRP2overexpression but not upon . . .
  

   

  

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