HIGHLIGHTS
- who: from the Biomedical Research Institute (IDIBELL), L`Hospitalet de Llobregat, Barcelona, Spain and , Chromatin Biology have published the article: SIRT1 / 2 orchestrate acquisition of DNA methylation and loss of histone H3 activating marks to prevent premature activation of inflammatory genes in macrophages, in the Journal: (JOURNAL)
- what: The authors investigate the links between SIRT1/2 activity and DNA methylation in macrophage differentiation due to their relevance in myeloid cells. The authors report a novel role for SIRT1/2 in the sequential and hierarchical deposition of DNA methylation, involving a direct interaction with DNMT3B, and . . .
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