HIGHLIGHTS
- who: Yasunobu Aoki from the Studies, Onogawa, Tsukuba, Ibaraki, Japan have published the Article: Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice, in the Journal: (JOURNAL)
- what: Based on the present and previous observations the authors propose that oxidative stress under conditions of mismatch repair deficiency accelerates the induction of single-adenine deletions at specific sites in oncogenes which enhances in a synergistic manner with G-to-A transition in other oncogenes (e_g Ctnnb1). The authors developed Msh2-KO mice carrying the gpt gene, and examined which mutations were frequently . . .
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