Digoxin absorption decreased independently of p-gp activity in rats with irinotecan-induced gastrointestinal damage

HIGHLIGHTS

• who: Toshiaki Tsuchitani from the , (7-ethyl-10-[4(-, piperidino)-1-piper-idino] carbonyloxy camptothecin have published the paper: Digoxin absorption decreased independently of P-gp activity in rats with irinotecan-induced gastrointestinal damage, in the Journal: (JOURNAL)
• what: The aim of this study was to quantitatively evaluate how activity changes in rats with CPT-11-induced as assessed by the of_(DGX) a typical substrate.
• how: The MS/MS analysis was conducted in negative-ion mode using electrospray ionization. In this study the concentration of CAM in the gastrointestinal tract was considered . . .
  

   

  

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