Pharmacokinetic predictions and docking studies of substituted aryl amine-based triazolopyrimidine designed inhibitors of plasmodium falciparum dihydroorotate dehydrogenase (pfdhodh)

HIGHLIGHTS

• who: Zakari Yau2019u Ibrahim from the (UNIVERSITY) have published the article: Pharmacokinetic predictions and docking studies of substituted aryl amine-based triazolopyrimidine designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH), in the Journal: (JOURNAL)
• what: The study focuses on the prediction of pharmacokinetic properties of sixteen substituted aryl aminebased triazolopyrimidine derivatives and their molecular docking as PfDHODH inhibitors to account for the causes of their interactions using the Molegro Virtual Docker (MVD).

SUMMARY

The speciesselectivity of these inhibitors is due to a difference in amino_acid sequence between the PfDHODH and hDHODH . . .

 



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