An engineered genetic circuit for lactose intolerance alleviation

HIGHLIGHTS

  • who: Mingyue Cheng from the (UNIVERSITY) have published the article: An engineered genetic circuit for lactose intolerance alleviation, in the Journal: (JOURNAL)
  • what: The authors initially designed and constructed a tristable-switch circuit in the plasmid pETDuet1-1 that had two functional states, which responded to signals of intestinal lactose and intestinal pH variation. For Phase II, during which lactose was fed to the model, control, and test groups, the objective was to investigate the influence of excess lactose on the gut microbiota. In Phase IV, the authors intended to observe whether the bacteria caused . . .

     

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