C-terminal p73 isoforms repress transcriptional activity of the human telomerase reverse transcriptase (htert) promoter*

HIGHLIGHTS

• who: Tomau0315su0316 Racek from the Tomau0301su030c Racek, Nikica Misu030ce, Zhenpeng Li, Anja Stoll, and Brigitte MPuu0308tzer, From the Department of Vectorology and Experimental Gene Therapy, University of Rostock Medical School, Schillingallee, Rostock, Germany Activation of telomerase is linked to tumorigenesis and has been observed in a variety of human tumors. Previous reports demonstrated that p, represses human telomerase reverse transcriptase (hTERT), a key component for telomerase activity. The p, protein displays a tumor suppressor activity similar to p53. In the present study, we examined the effect of transactivation competent p, isoforms on hTERT expression in p53negative human . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.