Aberrant dna hydroxymethylation reshapes transcription factor binding in myeloid neoplasms

HIGHLIGHTS

  • who: Jia Li from the (UNIVERSITY) have published the paper: Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms, in the Journal: (JOURNAL)
  • what: The authors report systematic genome-wide mapping of the hydroxymethylomes in over 70 patients with myeloid neoplasms. Taken together the authors provide a comprehensive 5hmC atlas representative of myeloid neoplasms which sets the stage for future exploration on the epigenetic etiolu2011 ogy of hematological malignancies. The authors reported the use of a substantially improved, highly sensitive CMS-IP-seq (sCMS-IP-Seq) method for genome-wide 5hmC profiling using low . . .

     

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