The down-regulation of xbp1, an unfolded protein response effector, promotes acute kidney injury to chronic kidney disease transition

HIGHLIGHTS

  • who: Jia-Huang Chen from the Graduate Institute of Toxicology, College of Medicine, National Taiwan University, No, Jen Ai road section, Taipei, Taiwan have published the Article: The down-regulation of XBP1, an unfolded protein response effector, promotes acute kidney injury to chronic kidney disease transition, in the Journal: (JOURNAL) of Mar/16,/2016
  • what: This study identified the XBP1-Trap1 axis as an instrumental mechanism responsible for post-AKI fibrosis which is a novel regulatory pathway. The authors propose that XBP1 downregulation can be a common pathway in post-AKI fibrosis. This study showed . . .

     

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