HIGHLIGHTS
- who: Fabrizia Fusetti from the LIA have published the paper: Structure of Human Chitotriosidase, in the Journal: (JOURNAL) of February/18,/2002
- what: By comparison of the active_site with that of chitinases from pathogenic organisms, the authors show that it should be possible to design allosamidin derivatives or other small_molecules that are selective inhibitors.
SUMMARY
The crystal_structure of the human chitotriosidase and complexes with a chitooligosaccharide and allosamidin are described. The structures reveal an elongated active_site cleft, compatible with the binding of long chitin polymers, and explain the inactivation of the . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.