Carboplatin-induced thrombocytopenia through jak2 downregulation, s-phase cell cycle arrest and apoptosis in megakaryocytes

HIGHLIGHTS

• who: Yi-Hong Wu et al. from the Department of Chinese Medicine, Chang Gung Memorial Hospital, Guishan, Taoyuan, TaiwanSchool of Traditional Chinese Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan have published the article: Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes, in the Journal: (JOURNAL)
• what: The authors used both carboplatin-induced CIT mice and MEG-01 cell line to examine the expression of JAK2 and signal transducer and activator of transcription 3 (STAT3) pathway. The association between decreased megakaryocyte viability and STAT3 activation in CIT found in . . .
  

   

  

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