Neuropathological and behavioral features of an app/ps1/mapt (6xtg) transgenic model of alzheimer’s disease

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• who: Sung Hyun Tag from the We used, xFAD (B SJL) Tg mice (The Jackson Laboratory, ME, USA) overexpressing mutant human APP K N/M L + I V + V I and mutant human , M L + L V [12]We also used, xTg (B SJL) Tg mice (The Gachon University, The Republic of Korea), in which hemizygous, xFAD transgenic mice were crossbred to , hemizygous transgenic mice [19]. Genotyping was performed by ear snipping, DNA isolation, and polymerase chain reaction (PCR) with the primers of PS1, APP, and MAPT. Wild-type littermates were used as control mice., mice were . . .
  

   

  

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