Thioredoxin-1 maintains mechanistic target of rapamycin (mtor) function during oxidative stress in cardiomyocytes

HIGHLIGHTS

• who: Shin-ichi Oka from the (UNIVERSITY) have published the article: Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes, in the Journal: (JOURNAL) of July/19,/2017
• what: Using a substrate-trapping mutant of Trx1 (Trx1C35S), the authors show here that mTOR is a direct interacting partner of Trx1 in the heart. The authors show that mTOR undergoes intermolecular disulfide formation in response to oxidative stress and that intermolecular disulfide bond formation at Cys-1483 is responsible for H2O2-induced mTOR inhibition. The authors showed that mTOR signaling is . . .
  

   

  

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