Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration

HIGHLIGHTS

• who: Luigi Racioppi from the DivisionDuke University Su00e3o Paulo, Su00e3o Paulo, Brazil have published the article: Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration, in the Journal: (JOURNAL)
• what: Cell Death and Disease Interestingly, the authors demonstrate that pharmacological inhibition of Camkk2 improves survival and accelerates HSPC recovery following hematopoietic radiation injury. The authors show Camkk2 deletion in HSPC significantly downregulates genes affiliated with the quiescent stem_cell signature . The results show CamKK2 may be the critical upstream kinase and the authors demonstrate radiation activates AMPK in HSPC via CaMKK2. The . . .
  

   

  

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