HIGHLIGHTS
- who: Cassandra L. R. van Doorn from the Department of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands United Kingdom have published the research: Pharmacological Poly (ADP-Ribose) Polymerase Inhibitors Decrease Mycobacterium tuberculosis Survival in Human Macrophages, in the Journal: (JOURNAL)
- what: The authors explore the potential of PARP inhibitors in the treatment of intracellular Mtb infections in human macrophages. The authors show that the inflammatory response of Mtb-infected macrophages is modified by pharmacological inhibition of PARP. The authors show that rucaparib decreased lactate production in Mtb-infected M1 and M2. This study has . . .
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