Icos controls foxp3 regulatory t-cell expansion, maintenance and il-10 production during helminth infection

HIGHLIGHTS

• who: Blackwell Medical from the Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK have published the article: ICOS controls Foxp3 regulatory T-cell expansion, maintenance and IL-10 production during helminth infection, in the Journal: (JOURNAL)
• what: This study shows that ICOS is partially required for the expansion and long-term maintenance of Foxp3+ Treg cells during H. polygyrus and S. mansoni infections, with the absence of ICOS leading to increased apoptosis of Foxp3+ Treg cells.

SUMMARY

43: 705-715 Treg-cell response in . . .

 



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