Snf1 phosphorylates adenylate cyclase and negatively regulates protein kinase a-dependent transcription in saccharomyces cerevisiae*

HIGHLIGHTS

• who: Raffaele Nicastro from the (UNIVERSITY) have published the research: Snf1 Phosphorylates Adenylate Cyclase and Negatively Regulates Protein Kinase A-dependent Transcription in Saccharomyces cerevisiae*, in the Journal: (JOURNAL) of April/13,/2015
• what: The authors propose a novel cross-talk mechanism between Snf1/AMPK and PKA pathways. The authors show that Cyr1 is a Snf1 target in_vitro and that its phosphorylation pattern is altered in_vivo in the snf1u232c mutant compared with the wild_type. Strikingly, the authors demonstrate that constitutive activation of Snf1 reduces cAMP intracellular content and functionally impairs PKA activity as a regulator . . .
  

   

  

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