Globally altered epigenetic landscape and delayed osteogenic differentiation in h3.3-g34w-mutant giant cell tumor of bone

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• who: Pavlo Lutsik from the Faculty Ruprecht Karl University of, Heidelberg, Germany have published the paper: Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors investigate the effects of H3.3-G34W on global epigenomic patterns in patient samples from four different centers. The authors demonstrate that neoplastic and non-neoplastic GCTB stromal cells represent distinct stages of osteogenic differentiation. To verify that the observed epigenetic changes were dependent on H3.3-G34W expression, the authors . . .
  

   

  

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