Cis-trans-amide isomerism of the 3,4-dehydroproline residue, the ‘unpuckered’ proline

HIGHLIGHTS

  • who: Vladimir Kubyshkin and Nediljko Budisa from the Institute of Chemistry, Technical University of Berlin, Mu00fcller-Breslau-Str, , Berlin, Germany have published the research work: cis-trans-Amide isomerism of the 3,4-dehydroproline residue, the u2018unpuckeredu2019 proline, in the Journal: (JOURNAL)
  • what: The authors report an experimental work investigating the basic physicochemical properties of two Pro analogues which possess a 3 4-double bond: 3 4-dehydroproline and 4-trifluoromethyl-3 4dehydroproline. The authors demonstrate that the 3 4-double bond in the investigated structures leads to an increase of the amide rotational barriers . . .

     

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