Heterodimers of serotonin receptor subtypes 2 are driven by 5-ht2c protomers

HIGHLIGHTS

• who: Imane Moutkine from the (UNIVERSITY) have published the paper: Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers, in the Journal: (JOURNAL) of April/14,/2017
• what: The authors show that 5-HT2Cu232cCter, which lacks the capacity of activating Gu2423q proteins, inhibits both Gu2423q coupling and ligand binding of associated 5-HT2 protomers.
• how: Saturation BRET experiments were conducted in HEK293 cells co-transfected with constant amounts of BRET donor plasmids and increasing amounts of BRET acceptor plasmids. Data were analyzed with one-way ANOVA for each graph and . . .
  

   

  

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