HIGHLIGHTS
- who: from the University of Edinburgh, Edinburgh, UK have published the research: Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation, in the Journal: (JOURNAL) of 25/Nov/2022
- what: To assess the effect of U18666a on cholesterol transport in the experiments , the authors first exposed bone marrow-derived mouse macrophages (BMDMs) and immortalized BMDMs (iBMDMs) to the compound and examined cholesterol localization by staining with a naturally fluorescent polyene antibiotic, filipin. In this study, by using pharmacological and genetic tools, the authors demonstrate that selective perturbation of the cellular cholesterol trafficking . . .
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