Apc controls wnt-induced β-catenin destruction complex recruitment in human colonocytes

HIGHLIGHTS

• who: Taybor W. Parker from the DepartmentUniversity of have published the paper: APC controls Wnt-induced u03b2-catenin destruction complex recruitment in human colonocytes, in the Journal: Scientific Reports Scientific Reports of 26/08/2019
• what: The authors examine the response of endogenous u03b2-catenin destruction complex components to a locally presented Wnt signal in human colon epithelial_cells of both malignant and non-malignant origin. The authors demonstrate that APC loss ablates Wnt-induced destruction complex localization. It is possible that these differences reflect more spatially restricted Wnt contact in the study compared to global . . .
  

   

  

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